G protein-coupled odorant receptors: From sequence to structure
نویسندگان
چکیده
منابع مشابه
G protein-coupled odorant receptors: From sequence to structure.
Odorant receptors (ORs) are the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with availa...
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Mammals detect and discriminate numerous odors via a large family of G protein-coupled odorant receptors (ORs). However, little is known about the molecular and structural basis underlying OR response properties. Using site-directed mutagenesis and computational modeling, we studied ORs sharing high sequence homology but with different response properties. When tested in heterologous cells by d...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2015
ISSN: 0961-8368
DOI: 10.1002/pro.2717